REACTIVATION OF THE TUMOUR SUPPRESSOR RASSF1A IN BREAST CANCER BY SIMULTANEOUS TARGETING OF DNA AND E2F1 METHYLATION.

Reactivation of the tumour suppressor RASSF1A in breast cancer by simultaneous targeting of DNA and E2F1 methylation.

BackgroundTumour suppressor genes are often transcriptionally silenced by promoter hypermethylation, and recent research has implicated alterations in chromatin structure as the mechanistic basis for this repression.In addition to DNA methylation, other epigenetic post-translational modifications that modulate the stability and binding of specific

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Severe intraoperative hypercarbia undetected by continuous end-tidal CO2 monitoring in a chronic smoker undergoing one-lung ventilation

One-lung onlyflans martina ventilation is known to alter the physiology and result in a discrepancy between end-tidal CO2 (ETCO2) and arterial blood CO2partial pressure despite protective mechanisms like hypoxic pulmonary vasoconstriction.Shunts in an emphysematous patient, quest fryer lateral positioning and capnothorax may aggravate the discrepan

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